This patient exemplifies a common finding in pancreatic cyst lesions: molecular alterations occur early in the molecular pathogenesis of this disease, and thus are the most helpful when first-line testing shows changes of a mild-to-moderate nature
While mutational change is detected, the extent is still within the range seen with benign or non-progressive disease
Patient continues to do well under surveillance for 56 months
Molecular analysis provides full support for AGGRESSIVE disease
Cytology of the sampled solid component failed to identify atypia or malignancy
Surgery was performed, disclosing pancreatic adenocarcinoma occupying part of the cyst wall lining
Limitations and Disclaimers1
Although PancraGEN is highly specific for malignancy, some malignant cysts may not be detected. There may also be individuals who are falsely identified as having a malignant cyst. Diagnosis and appropriate patient management are the responsibility of the referring physician or healthcare provider.
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Loren D, Kowalski T, Siddiqui A, et al. Influence of integrated molecular pathology test results on real-world management decisions for patients with pancreatic cysts: analysis of data from a national registry cohort. Diagnostic Pathology. 2016;11:5. doi:10.1186/s13000-016-0462-x.
Gaujoux S., , Brennan, M., et al. Cystic Lesions of the Pancreas: Changes in the Presentation and Management of 1,424 Patients at a Single Institution over a 15-year Time Period. J Am Coll Surg. 2011 April; 212(4): doi:10.1016/j.jamcollsurg.2011.01.016.
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